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Carbonic Anhydrase : Mechanism, Regulation, Links to Disease, and Industrial ...

Description: Carbonic Anhydrase : Mechanism, Regulation, Links to Disease, and Industrial Applications, Paperback by Frost, Susan C. (EDT); McKenna, Robert (EDT), ISBN 9402402500, ISBN-13 9789402402506, Like New Used, Free P&P in the UK The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Even Hans Krebs contributed to early studies with a paper in 1948 showing the relationship of 25 different sulfonamides to CA inhibition. It was he who pointed out the importance of both the charged and uncharged character of these compounds for physiological experiments. The field of study that focuses on carbonic anhydrase (CA) has exploded in recent years with the identification of new families and isoforms. The CAs are metalloenzymes which are comprised of 5 structurally different families: the alpha, beta, gamma, and delta, and epsilon classes. The alpha class is found primarily in animals with several isoforms associated with human disease. The beta CAs are expressed primarily in plants and are the most divergent. The gamma CAs are the most ancient. These are structurally related to the beta CAs, but have a mechanism more similar to the alpha CAs. The delta CAs are found in marine algae and diflagellates. The epsilon class is found in prokaryotes in which it is part of the carboxysome shell perhaps supplying RuBisCO with CO2 for carbon fixation. With the excitement surrounding the discovery of disease-related CAs, scientists have redoubled their efforts to better understand structure-function relationships, to design high affinity, isotype-specific inhibitors, and to delineate signaling systems that play regulatory roles over expression and activity. We have designed th to cover basic information of mechanism, structure, and function of the CA families. The authors included in this book bring to light the newest data with regard to the role of CA in physiology and pathology, across phylums, and in unique environmental niches.

Price: 174.24 GBP

Location: Castle Donington

End Time: 2024-12-04T08:48:56.000Z

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Carbonic Anhydrase : Mechanism, Regulation, Links to Disease, and Industrial ...

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Book Title: Carbonic Anhydrase : Mechanism, Regulation, Links to Disease, and

Number of Pages: 430 Pages

Language: English

Publication Name: Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications

Publisher: Springer

Publication Year: 2016

Subject: Medicine, Chemistry, Biology

Item Height: 235 mm

Item Weight: 6613 g

Type: Textbook

Author: Susan C. Frost, Robert Mckenna

Series: Subcellular Biochemistry

Item Width: 155 mm

Format: Paperback

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