Description: Evaluation of Enzyme Inhibitors in Drug Discovery : A Guide for Medicinal Chemists and Pharmacologists, Hardcover by Copeland, Robert A.; Walsh, Christopher T. (FRW), ISBN 111848813X, ISBN-13 9781118488133, Brand New, Free shipping in the US Specifically intended for chemists in pharmaceutical laboratories and for pharmacologists, this second edition text updates the 2005 first edition. The first chapter discusses the advantages of enzymes as drug targets. Following is coverage of enzyme reaction mechanisms, reversible modes of inhibitor interactions with enzymes, assay considerations for compound library screening, lead optimization and structure-activity relationships for reversible inhibitors, slow binding inhibitors, tight binding inhibition, drug-target residence time, irreversible enzyme reactions, and quantitative biochemistry in the pharmacological evaluation of drugs. Ten appendixes support the text. Annotation ©2013 Book News, Inc., Portland, OR ()
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Book Title: Evaluation of Enzyme Inhibitors in Drug Discovery : A Guide for M
Number of Pages: 576 Pages
Language: English
Publication Name: Evaluation of Enzyme Inhibitors in Drug Discovery : A Guide for Medicinal Chemists and Pharmacologists
Publisher: Wiley & Sons, Incorporated, John
Subject: Life Sciences / Biochemistry
Publication Year: 2013
Item Height: 1.3 in
Type: Textbook
Item Weight: 32.4 Oz
Subject Area: Science
Author: Robert A. Copeland
Item Length: 9.6 in
Item Width: 6.5 in
Format: Hardcover
