Description: Protein folding and misfolding: neurodegenerative diseases Please note: this item is printed on demand and will take extra time before it can be dispatched to you (up to 20 working days). Author(s): Judit Ovadi, Ferenc Orosz Format: Hardback Publisher: Springer-Verlag New York Inc., United States Imprint: Springer-Verlag New York Inc. ISBN-13: 9781402094330, 978-1402094330 Synopsis It was twenty ?ve years ago this year that for the ?rst time a protein under- ing a form of human cerebral amyloidosis, the Icelandic-type hereditary cerebral haemorrhage was identi?ed. This, together with the recognition that an amino acid substitution can transform the wild type cystatin C into a disease-associated amyloid-forming protein in this condition, was only a prelude to a series of imp- tant discoveries that followed. As a result, pathologically altered proteins have been brought into the centre stage of research into the pathomechanism of a n- ber of neurodegenerative diseases, which include epidemiologically such important conditions as Alzheimer's disease or Parkinson's disease and, among others, also the transmissible spongiform encephalopathies, Huntington's chorea, spinocereb- lar ataxias, frontotemporal lobar degenerations and amyotrophic lateral sclerosis. Despite the diversity in the amino acid sequence of the different proteins involved in these neurological diseases, one of the common themes underlying the patho- chanisms of all these conditions is protein misfolding, aggregation - hence the term protein folding disorders -, which can trigger cascades of events ultimately resulting in synapse loss and neuron death with devastating clinical consequences in many of the most precious spheres of human existence including personality, cognition, memory, skilled movements and affection. It is always a challenging task to unite the different topics of the individual ch- ters into a common theme in a multi-author volume, but the current book edited by Judit Ovadi and Ferenc Orosz ?ts this task admirably.
Price: 104.29 GBP
Location: Aldershot
End Time: 2024-12-26T08:51:42.000Z
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Book Title: Protein folding and misfolding: neurodegenerative diseases
Number of Pages: 278 Pages
Publication Name: Protein Folding and Misfolding: Neurodegenerative Diseases
Language: English
Publisher: Springer-Verlag New York Inc.
Item Height: 235 mm
Subject: Medicine, Chemistry, Biology
Publication Year: 2009
Type: Textbook
Item Weight: 666 g
Author: Ferenc Orosz, Judit Ovadi
Item Width: 155 mm
Series: Focus on Structural Biology
Format: Hardcover
